Comparison of Intrathecal Nalbuphine Versus Intrathecal Buprenorphine As An Adjuvant to Intrathecal Bupivacaine for Postoperative Analgesia in Patients Undergoing Lower Abdominal Surgeries,

Objective: To evaluate and compare the characteristics of spinal block, its postoperative analgesic effects, using intrathecal inj. Bupivacaine 0.5% and its combination with nalbuphine or buprenorphine in patients undergoing lower abdominal surgery. Methods: Sixty patients aged 30-60years scheduled for elective lower abdominal surgeries randomly received hyperbaric bupivacaine 0.5% 2.6 ml (group BN control, n = 30) with buprenorphine 60 micrograms [DOSAGE ERROR CORRECTED], or nalbuphine 0.8mg [DOSAGE ERROR CORRECTED] with hyperbaric bupivacaine 0.5% 2.6 ml(group BN, n = 30). Characteristics of spinal block, hemodynamic stability, postoperative analgesia. Results: The mean time for Effective analgesia (VAS 0-3) was 285±94. 46 min in group BN as compared to 383.67 ± 79.20 min in group BB. This was statistically and clinically significant in this study (p<0.001). The mean duration of requirement of first rescue analgesia in Group BN (354±106.69) and Group BB (425±81.53) showed statistically significant difference (P=0. 0053), this has highlighted the fact that Group BB had prolonged post-operative analgesia. Conclusion: Present study shows effective analgesia in BB group is 383.67 ± 79.20 min and time to rescue analgesia is 425 ± 81.53 min while compared to BN group effective analgesia is 285 ± 94.46 min and time to rescue analgesia is 354±106.69 min. Hence we concluded that intrathecal buprenorphine 60 μg when compared to intrathecal nalbuphine 0.8 mg causes prolonged duration of postoperative analgesia.